AI-powered peptide intelligence by Framework Island. Evidence-based, editorially rigorous, and committed to transparency in peptide science.
GLP-1
Semaglutide has transformed the treatment of type 2 diabetes and obesity. Marketed as Ozempic for diabetes management and Wegovy for chronic weight management, this once-weekly injectable GLP-1 receptor agonist has become one of the most prescribed medications in the United States — and for good reason. Clinical trials show average body
Peptides
Selank is a Russian-developed synthetic peptide approved for generalized anxiety disorder that offers anxiolytic effects comparable to benzodiazepines — without the sedation, dependence, or cognitive blunting.
Peptides
BPC-157 has generated more scientific attention than almost any other research peptide. Here's what the evidence actually shows — mechanisms, benefits, dosing, and 2026 legal status.
GLP-1
Orforglipron (Foundayo) is the first true oral GLP-1 receptor agonist — FDA approved in April 2026. Here's the complete guide to how it works, clinical results, and who it's for.
Peptides
Epithalon is a pineal-derived tetrapeptide that activates telomerase and may extend telomere length. Here's what the science says about dosing, benefits, and safety.
Peptides
Melanotan II (MT-II) is one of the most talked-about — and most misunderstood — peptides in the research community. Originally developed as a tanning agent at the University of Arizona, it inadvertently became the foundation for the first FDA-approved drug for female sexual dysfunction. Today, it remains a subject of intense scientific
Peptides
If you have spent time researching peptides for growth hormone optimization, you have almost certainly come across GHRP-6 and GHRP-2. Both belong to the same family of synthetic growth hormone secretagogues, both activate the same primary receptor, and both can meaningfully increase GH pulsatility. Yet in practice they behave quite
GLP-1
A new class of obesity treatment is emerging — and it's more powerful than anything that came before it. Retatrutide (LY3437943), developed by Eli Lilly, is a first-in-class triple receptor agonist targeting GLP-1, GIP, and glucagon receptors simultaneously. Phase 3 data shows average weight loss of up to 28.
Peptides
Most drugs that treat sexual dysfunction work by improving blood flow. PT-141 takes a completely different approach—it works on the brain. Also known by its generic name bremelanotide, PT-141 is a melanocortin receptor agonist that activates specific neural pathways involved in sexual motivation and arousal. It's the
Peptides
If you've spent any time researching peptide therapy or growth hormone optimization, you've almost certainly come across the CJC-1295 and Ipamorelin combination. This stack has become one of the most popular peptide protocols in both clinical anti-aging medicine and the broader biohacking community—and for good
Peptides
GLP-1
Semaglutide and tirzepatide have transformed obesity medicine. The average person on tirzepatide loses 20–22% of their body weight; on semaglutide, 15–17%. Those are numbers that previously required bariatric surgery. But there's a complication the prescribing literature doesn't emphasize enough: a meaningful portion of that